Jazzy Vee,
I have a Strat and an Orion. Bear in mind that I am not a professional musician. My wife's a stay-at-home mom and I'm a play-at-home dad. For me, going on tour means taking one of my guitars and heading from my den to the basement. But here's my two cents.
The Orion sounds nothing like the Strat...I don't think anything really does. Sure, run a guitar through enough pedals and any one will sound pretty much like another...but out of the box and through the amp...no way. The Orion does, however, deliver wonderfully crisp tones through a clean amp. Turn the bass up a bit and the treble down and you get a nice, warm and full sound. Through an overdriven/distorted amp, the Orion rocks just as hard as my Les Paul and PRS...so don't worry about that Santana tone. You will not go wrong with the Orion being your Jack of all Trades!
It is dependent on the 9v battery, but the active pickups are hardly a drain on the power so they seem to last forever. I don't play the Orion all the time, but it's been at least a year...I think...since the last battery change.
Never had a problem with noise interference.
Because of the extended upper horn, the Orion will not fit into a case that is cut specifically for the Strat.
Hope this helps,
Jonathan