The most important thing to know is that flat is 2-10-2 (bass 2, mid 10, treble 2). So you can boost bass and treble, mid you can only cut.
Going mono, I usually set the bass to 4 or 5, mid 5 or 6, and treble anywhere from 1-5, depending on the sound I'm going for.
Going stereo, are you going to go to two separate amps, or use the F-2B to combine the signals?