KEEP IT SIMPLE AND DRIVING without losing the groove or abandoning dynamics.
Very few players, with the exception of those like Entwistle & Lee, are successful with incorporatingembellishments into a rock setting. It works for them because their bands accommodated their playing styles. You might not be so lucky.
Re: amp tone - I prefer a crisp, slightly distorted tube tone (SVT, driven Fender, etc.) as it sounds full and the inherent mid bump from the natural overdrive sits nicely in the mix without sounding tubby.
And round wound strings.
To pick or not - personal preference. I prefer not because I feel I have more control over dynamics with my fingers, especially since I've started to incorporate the typewriter tapping style into my arsenal of techniques. This technique works well with the above-mentioned tone and delivers a punchy, ringing sound that really cuts through when needed.