Here is my understanding of the issue. If you are running 4 cabinets, two off each channel, then if they are 8 ohm cabs, the load on each amp channel (assuming parallel connection) will be 4 ohms. If those same 4 cabs were 4 ohm cabs, then the load on each amp channel would be 2 ohms. Many amps cannot handle a 2 ohm load safely for an extended period of time; thus 2 ohm loads are, as a general rule, avoided. (There are of course amps that can handle a 2 ohm load with no problem; it's a general rule not a hard and fast rule). A four ohm load makes more efficient use of your amp's power capabilities than an eight ohm load. In the case of the 2402, each channel provides 700 watts into 4 ohms, but only 425 watts into 8 ohms. (The PLX 1602 is 500 watts into 4 ohms or 300 watts into 8 ohms). Thus, if you only use one cab off each channel, then four ohm cabs will be preferable to eight ohm cabs; but if you are typically running 2 cabs off each channel then the 8 ohm cabs might be a better choice.