Read all the replies, one was interesting about a good amp, when I visited the Alembic factory in 2000(I am from the UK) I talked to the MAN himself Ron Whickersham(I am not worthy!!!) who said all that is needed is a good quality power amp with a gain control and a matching speaker with tuned cabinet, he said his circuits are all that is needed and the amp & cab are there to transfer the sound to the ears. Alembic could build you one if needed but having took that info on board I now have all the EQ totally set at centre zero with no boost or cut..and you know he is right(heaven forbid if he was wrong!)
There is enough tonal parameters in the Signature and I would imagine even more with the variable Q controls on the Series at your fingertips.
Oh yes for the fender sound, for jazz, pan biased slightly towards bridge PU, Q's off, bridge filter at mid point, neck filter at a few degrees from mid point to treble end, play the strings at the bridge PU, for precision, pan to neck PU, filter a few degrees to the bass side.
Suppose it depends on style, amp etc as well..I use Peavey
Terry C