Cocobolo's gorgeous, in addition to sounding great..
I think if anything, a chambered body would adversely affect fundamental sustain (if you can hear it acoustically, then energy is being dissipated) but not so much the overtones (where Cocobolo shines). With a fairly rigid neck-through, a pound of brass under the bridge and series components, I think any losses resultant from the loud chambered body are more than mitigated.
I'd love to hear Series guts in a true solidbody, but it would be effectively chambered by the time you did enough routing for Series guts to fit!
Of course, after spending a fair amount of time with my Hofner I'd be interested in Series guts in a true hollowbody... (I need to borrow Paul TBO's stocking first!)
John