I have to disagree with the above statement, at least with regards to fuzz pedals. There have been many posts where it was suggested that simply adjusting trim pots or rolling back volume will produce the same tone in a Fuzz pedal as achieved with a passive guitar. This is simply not the case (at least with my Zvex Fuzz Factory, Octane III, Woolly mammoth, or any other germanium fuzz I have used). All that having been said, I never encountered any problem with modulation pedals, and I suspect wah and compressor would be fine as well.
Those primitive fuzz boxes just do not respond to buffered circuits at any level. Funny enough, I thought my Rat, Boss, and DOD distortions all saounded better than my germanium transistor fuzzes. Still not great, but better. I think you will find most of the guitar folks around here achieve their distortion by running Mesa Boogies hot.
This phenomenon eventually led me to sell my Alembic guitar (more money in effects than I had in guitar), and buy an Alembic SF-2. Now I can put my fuzzes between my Giffin and my sf-2, and get alembic filtering with sweet fuzz tone. The best of both worlds really. This would be my suggestion for a die hard fuzz/distortion lover, if you have the resources, and can find a good playing passive guitar, of course.