It all matters.
I never get into these discussions elsewhere, because I don't like to argue for what I already believe, quite firmly. I'm not going to change my mind until my ears tell me to. That, and there's always some guy who want to convince me a cardboard box guitar is just as good. And I'm cool with that... go 'head.
What Bill said. It was a hard thing to accept, because I had played guitar with a thick, hard pick since... forever, (thanks to Norman Blake and Tony Rice, et al...) but as I tried to expand and grow into an electric guitar player, it didn't work. No matter what I did, it didn't sound like I wanted it to, so I had to adapt. A lighter pick was required for the much lighter gauge strings. Not to mention the lighter touch. So, it was not only the instrument, but accessories, and the user being familiar with the operational limits of the tools. I have also learned, even though I am not a fingerstyle player, that I can pull double and triple-stops with free fingers, while plucking. Could have been doing this all along, but never needed to. Point being, that was a whole new sound I could access and now having to plug in. And... all this directly affects how the controls are set on the instrument. And the amp. What a loop.
My Dad used to repeat often about building our banjos; [paraphrasing] that it was most important that nothing be in a bind, to set the instrument up 'neutral'. Everything should fit together and be flush and plumb, nothing force-fit or sloppy. A sloppy neck-to-shell joint absolutely kills one, no sustain, no ring. If I heard this once I heard it a thousand times. I think it's directly related to why the neck-through construction of an Alembic supports sustain so well... it eliminates ways for sustain to be diminished.
I like Jimmy's analysis. My two Alembic 5-strings are built on each other's specs, on purpose. 32" medium-scale, 3 purpleheart laminates in a maple beam, mahogany body core, maple faces, a fretted one fretless, both profiled alike. Electronically, very similar too. The Custom has a couple extras, but essentially the same core V/P/F/Q-3 set. They came out sounding close enough. Yeah, there's some differences, but subtle enough that I doubt if anyone but me notices. If they notice anything, it's my sketchy intonation on the fretless.
I'd have to say, I still sound like me on either one... and that was precisely the idea - so I could switch between the two of them interchangeably.