Pedals always. I use every kind of pedal, all modulations, fuzz overdrive, delay, reverb you name it. Its the same board for Bass and Guitar I don't notice any freq loss on either. Mostly DIY.
And loopers too, always at least two, usually 4.
Les Claypool is my effector inspiration. He's a master of poignant effects application in songs.
An effect can change the mood or expression in a line, or add an ambiance to a progression, and keep things dynamic and fresh.