Well...as an experienced "Spyderman" :-) some comments from my side:
Playing the first notes of my brand new Spyder built in 2015 made me also think...Mhhh...main output level is a bit weak compared to my other bass guitars...so I turned the internal trim pots to maximum level. Next thing I had to do was lifting up the strings a bit - I play like "The Ox" using the typewriter style, factory settings of the string's height made them vibrating on the frets.
Next then was turning the filters away first and ignore the Q-switches for a while, just for finding the correct balance between the PUs. Optimum for me (but that's very individual - depending very much on the style you are playing!) is to turn the neck PU to max. and the bridge PU to 2/3 volume. Next thing of course are the strings! I use ELIXIR strings - they don't have that brilliance right from the beginning, but they keep their sound for a very long time, just until the nano coating starts to crackle away. My rig just consists of a TC RH750 top and a Phil Jones C8 Lite cab - a perfect counterpart for the Spyder! The only pedal I have in use is the Boss Octaver OC-3. I love the TC head becaus it's programmable, I have programmed 3 "basic" sounds: First one having a bass boost in the low-down range fro getting a fat sound - overwhelming when activating the Octaver while having switched the Spyder to the bridge PU only! 2nd setting is a "funky" one, boosting the mid/high range. Turning up both PU volume pots to the max, the sound is exactly like in Melissa Etheridge's "Like the way I do" - or to The Who's "Can't explain". 3rd amp setting is a mid-range boosted one, enhanced with a very small part of the built-in tube sound simulator. This setting combined with the Spyder's volume pots set to neck PU 2/3 and bridge PU full leads to a "Flea-like" sound, I use that e.g. for playin' "Around the world".
So far for the basic settings - if needed, I also activate the filter pots on the Spyder, e.g. for playing "jazzy" parts with less treble - but that's also a very individual thing to do, just try it yourself.
Hope that helps a bit...