Randall Smith and Mesa will quickly tell you that the first amp they made was a bass amp. Over the years, they have steadily turned into quite a force in bass rigs, and 800 / 800+ are hits, riding the Class D amp / neo cab wave. Their tube amps are my-t-fine as well.
For a Neanderthal like me who easily remembers folded 18 cabs and 80# SVT heads (or Heaven help us, those 150# Macs), it is utterly amazing to see what has now become common today. I've been jealous my whole life that a &%*#( guitar player could show up with a guitar and a single 12, 100w amp and he's ready to go, while I was in the furniture moving business to try and compete on stage. Interestingly, I'm almost there now.