I am blessed to be in a band with a keyboard player who is more than willing to give me as much sonic room as I can take. He laughs out loud when I play full chords at the low end of the neck and tells me it's great, whether on the Alembic or the 12-string. Of course, I get to play lots of notes and chords all over the neck. Nobody complains at all, because I only do it when it *needs* to be done. I would be lost with only 2 strings - even more so if they were tuned to the same note. Therefore I respect fully the people who can be musical and creative with such a limited palette. Mark Sandman really did some cool stuff that would be difficult to play with extra strings in the way, very reminiscent of blues guitar but played low on the bass. I find it inspirational.
I find that anymore I tell people before I even agree to play that I am genetically incapable of playing anything exactly like the recording. I will nail the style to the best of my abilities and keep things in the pocket as best I can, but I think when I play and that usually results in a creative turn here and there even when I'm trying my best to be mind-numbingly simple.
John