I think maybe Dave and Stoney are confusing power rating and efficiency ratings for cab matching purposes. Standard practice is to use a cabinet that will handle more power than your head puts out, thus avoiding speaker failure when pushing the limits. The power rating of the cabinet makes no difference to the head. What *does* make a difference is the efficiency of the cabinet--i.e., how much acoustic output you get for watts in. Acme cabinets, for example, are relatively inefficient and require lots o' watts. In general, buy a cabinet that is rated for at least the same RMS power as your amp puts out. A cabinet rated higher than your amp will not suck the life out of the amp, unless it is Acme-like in its efficiency, or lack thereof.
The main reason that I prefer Speakons to 1/4 connectors is that their contact area is much larger than the tip of a 1/4 jack, thus allowing better power transfer. Admittedly, this is only a factor at higher power levels, but still, if you're picky enough to play an Alembic, you might as well do the speaker connections in the most effective way possible, IMO.
Speaker configuration is more and ear call than anything. Personally, I like smaller drivers (10's until I acquired my GenzBenz 212 with Neodymium drivers) for everything but the bottom octave, where 15's and/or 18's can't be beat. I don't like the midrange character of the larger drivers, which is why my large rig is biamped, crossover at 70-100 Hz, depending on venue and volume. Ported 410's (e.g., the Ampeg 410HLF)tend to have a somewhat exaggerated yet (to my ears) artificial sounding bottom end.