This is ssoooooo subjective.
I'd have to agree with my peers: It all depends what YOU are after PLUS who's sound is in the back of your mind that you want to replicate.
Oh if it was only as simple as just duplicating your favorite player's rig . . . but that won't do it.
My only recommendation is to stick with stuff that's well-designed and built. Here in Nashville with so many touring acts, my first question is does this hold up on the road?, as there's lots of people to answer that question!
I rarely gig anymore, so anything on the YES list of that question will hold up forever for me.
Of the amps built on an 'industrial' scale, Mesa's are at the top of most lists. Ask any dealer how many service calls they get on them, and you get this blank stare while they try to remember the last time they had to fix one !
Lower down the ladder, the Fenders (especially some of the Custom Shop Tone Kings or the Cybers) and Peaveys (5150s and the new Joe Satriani head to name a few) are well built. They don't have Mesa's tone, but they don't cost as much either.
My sentimental favorite (that's utterly useless for distortion) for CLEAN is the Roland JC120. Two power amp-spec amps, unearthly chorus, built like a tank (but they were better when you could get them with JBLs).
The 'boutique' amps are very tasty, but can be problem children with no service very close to you. Can eat up a lot of freight (on YOUR nickel) sending 'em back.
For me, Swiss Army Knife of guitar amps will always be Fender's Twin Reverb: Loud as hell if it has to be, portable, smooth enough for archtop jazz, plenty twangy with a Tele, smoking with a Paul or PRS. Get a matching 212 bin to put under it, you can go anywhere and play anything. Of course, running TWO of 'em in stereo with a SKYLARK and a Lexicon would be out of this world (and loud as hell . . .)
Having demonstrated my limited experience, be sure and understand there's LOTS of good amps out there. Good Luck!
J o e y