I'd DEFINITELY string it up with whatever you're thinking of using with your guitar 'as is'. It's a one-way trip as Jimmy said, you can always perform surgery later once you're sure it's what you want.
You could always take the slotted top half of the nut off and save it, get a new blank from Alembic and cut it for your new sizes.
I would NOT want to use 'V' slots. The prevailing wisdom has always been to use the round slots, 1/2 the depth of the string diameter. Amazingly, lots of basses are cut that way for the big strings, yet the D/G/C strings are submerged in way deeper slots. Especially for slap guys, I could see the strings jumping out of the V slots.
J o e y