I think if you run 8 and 4 ohm cabs in series, you wind up with a 12 ohm load. On my boogie I have 3 speaker outs, 8, 4, and 4 ohms. The folks at Mesa tell me I can use any of them, so long as the cab ohm rating is equal to, or greater than the amp outs. Thus, in Dave's situation I would plug the 4 ohm cab into the 4 ohm out, and the 8 ohm cab into either the other 4 ohm out or the 8 ohm out, whichever sounds better. Of course this is for a Boogie Mark amp. Your situation may be different.
Bill, tgo