I started out back in the day with 215 acoustic and a 610 sears cab. Blew them up because I didn't know about watts ohms etc. Started using a 410 and 15 in 82-83. Compressors, eq's and all that goes with it plus deltalab efx etc. After going through Sunn 412, 18 w bin, 210, 410 of various brands I now settled on 212 cabs, I have a 610 as well but never take it out.
The 410s were good, tight , focused and punchy. The 15 worked well because I also played synth pedals through it and the sub waves were handled. I know quite a few guys who are sold on svt 810's (but they don't have to move them) I never felt that the pronounced lows were there but the mids were in your face.
The best over all to my ear right now is 212's. Plenty of lows but very good articulation. My cabs have tweets so the sizzle is there if I need it though I generally dial it down. It took me way too long to realize that my rig was really just my stage monitor and the FOH guy will do what he wills to my sound.
To answer your question about the heads sound with diff. cabs. Absolutely. My 610 sounds better with the Thunderfunk than the Epifani, but the 212's sound better with the Epi.