I use to run a 12 U guitar rack in my studio that comprised:
Triaxis, JMP 1, Quadraverb Q20, 2 X AKAI MB76 midi controlled mixers, AKAI PEQ6 midi controlled EQ, Digital Music Corp System MIX Plus, DMC GCX switcher, my power amp was a Marshall EL34 50/50 and it fed a pair of marshall cabs with Celestion GT12/75. It was all controlled with a DMC ground control.
I could plug in pedals or other efx in series or parallel and could pretty much set up almost an kind of sound. It was after all meant to be versatile in the studio.
I dealt with all kinds of guitarists from HM to punk to jazz and ran then through this rack. It was a system I liked a lot. Eventually I found after years and years of tweaking settings &presets, that I gravitated towards the Triaxis run clean, feeding the power amp either clean or full out for that spongy power amp distortion that you cannot get from preamps alone.
I wish I still have that rack, I still have some bits but sold the triaxis, JMP1 and marshall power amp. I could run the set up at full blast at 3 in the morning in my old studio, but now I can't in this new place until my new studio is finished. It was nice to have all that flexibility. Will I build a new rack? Maybe. But as you get older your need for distortion drops.....in life and in guitar haha.
For guitar now I use a Trace Elliot V type via a crossover, or a F1-X. The Alembic has a built in crossover, so if you feed the low out and set the crossover at 3.2KHz or thereabout you have instant speaker simulator. I run various fuzz boxes, a rat, a couple of TS808s and a custom one that was made for me to get a VOX distortion sound. I run it all direct. I don't gig on guitar anymore, 99% of my gigs are on bass. But when I did I ran the set up via a Carver power amp, and used the full range output. I do a lot of guitar work in the studio but I do miss a tube power amp somewhat but not enough to go get one now.