Agreed on the Mesas. I do have a RoadReady 2x10 and I have to think A LOT OF TIMES before moving it out of my studio. I had me built a couple custom 2x10's which are lighter, although not so clear-voiced. I don't want to swap speakers, tho, so for medium/small venues I end up bringing one or two of the custom made 2x10s (one is based on an Eden cab, the other on an SWR a little bit smaller), and the beater Hartke HA2000, and that solves it. For smaller venues, it's the GK 200MB with -or without- an external, Eden loaded 1x10.
For bigger venues, I've had the luck to be able to ask for backline amplification. In those cases i bring a 4spc rack with my Yamaha PB-1 preamp, DBX 163x compressor, and a Digitech RDS delay unit I set up for chorus, and wireless if needed. The Preamp has a built-in, regulable XLR DI out to the board, and I go out of the jack out to whatever I get for backline (sometimes a hit, sometimes a miss) and ask, if needed, for a little bass on the sidefills. But for those larger shows/venues I find almost preferable that, to lugging around the heavy boxes, I tend to use them each time less, only at my studio if I'm rehearsing or stuff...