That's exactly what I do. Two F-1Xs and an SF-2 powered by a Yamaha 3500S. I have to admit I don't use the stereo option as much as I probably should. However I think that to really hear and feel a significant difference I'd need to get a new speaker cab. When I go stereo at this point, I'm running one PU through a PJB 8 x 5 cab and the other through a PJB 16 x 5. To be honest, I don't hear that much of a difference unless I'm really doing something dramatic with the filters or running one PU through my Lexicon MPX 1 processor.[size=78%] [/size]