Jared:
It's set-neck vs. neck through. On a neck through (or neck thru) instrument, the same piece of wood (or pieces with a laminated neck) runs the entire length of the guitar. Wings are then glued to the sides of the neck to form the body. Examples are Alembic Series instruments and the Further, Spectrum, Little Darling, and California Special guitars. On a set neck, the neck is a separate piece from the body and glued into a neck pocket (as opposed to bolting into a neck pocket, like a strat). Examples are Alembic Orion, Skylark, and Tribute guitars, along with most Gibson guitars (Les Paul, SG, ES335).
Bill, tgo