I'm not a guitar player, and I don't own a guitar, so I may be completely off base here, but what I've noticed with my six string is that how the highest string sounds is very dependent on your rig's EQ settings.
For instance, if you are using a Fender style amp (like an F-2B or F-1X), the bass, mid and treble controls are interactive. A slight adjustment to either the mid or treble control will move the entire high end portion of the curve, affecting how the top string sounds. Additionally, if you have an SF-2 in your rig, you can smooth out the high end portion using the high pass filter, making high end response more consistent over a wider range. Working with the F-2B and SF-2 together, you can shape the curve to best support your particular instrument.