Hello,
I have often wondered about this, because I started taking extended release B-12 pills about a year ago. The percentage per pill that is listed is...wait for it...16,000%!!! OK, that's a lot right? Well, I'll say this:
I started taking them because I had possible nerve damage in my right arm, which obviously concerned me because like the rest of us here, I live for playing bass. The therapist suggested eating greens and, in general, getting vitamin B. I got the pills and, though I can't confirm any benefit to the nerve damage, I can say that I stopped getting sick. The only time I got sick was after I ran out of B-12 and was too lazy to go buy more.
I never felt or saw any ill-effects at the time. Of course, who knows what long-term effects I was doing, positive or negative, to myself, but the sick thing was a great benefit for someone who frequently got head colds and sore throats.
An interesting thing about the extra % of B-12 is how it likely worked with my Prilosec pills, which neutralize acids in my stomach. The thing about vitamin B is that it *needs* acid to release itself from proteins that it attaches itself to after you've injested it. I guess what I'm saying is I'm deducing that I need to take some (though maybe not all 16,000% of it) extra B-12 for it to do any work for me.
Sorry for the long post, but I find this stuff really interesting. Cheers, Jeramaya