Bob's (bsee) post is a good one, in my opinion, regarding the differences in sound between Series and non-Series pickups and electronics. My first DW had Signature electronics with 3-way Q option. While waiting for its replacement, I got a Series II and realized the available sound palette was different. I then asked Mica to change my second DW to Anniversary, but keep the 3-way Q and add a 5-pin connector so I could use it with the DS-5R.
To follow up Wolf's comment, I also use a Furman conditioner, DS-5R to split the signal for two F-1Xs and a SF-2, then into a QSC RMX2450 and/or a Crown Ti4000 (stereo or bridged amps, depending on the venue). There is some material for which I prefer the Anniversary electronics and with others, the Series.
Among the many great things about Alembic are the choices we have to get the sounds we desire.