The Thomastik flats just hit all the right resonances, and are so very easy to play. Plenty of bottom, articulation and control. I've tried about every other string on the market, including the Pyramids (which make excellent, full-sounding roundwounds), but have to say that the Thomastiks are the ultimate Alembic string.
My birdseye maple Orion has Essence tone controls. I usually play the favoring the neck pickup and with the tone control nearly up into an early model Euphonics iAmp and Euphonics cabinet. I don't bother with the tone controls on the amp, and get plenty of growl, while the tonal balance is outstanding.